At Lansdale, I always stayed at Homewood Suites on Church Road. From the hotel, I would run down the Church Road to Sumneytown Pike, continue to the entrance of Merck campus, and then back up on the Church Road. Sometimes I would go straight to the hotel, and sometimes I would continue to Main Street and then back to the hotel.
This was not the most pleasant route, most of it was on busy streets, but any run is better than no run I guess. On the day when I recorded this, my total running distance was about 4.5 miles.